The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 30, 2021
Filed:
Aug. 06, 2019
Fresenius Kabi Deutschland Gmbh, Bad Homburg, DE;
Thomas Solacroup, Blonay, CH;
Matthieu Stettler, Vucherens, CH;
Martin Jordan, Ecublens, CH;
Hervé Broly, Chatel-St Denis, CH;
FRESENIUS KABI DEUTSCHLAND GMBH, Bad Homburg, DE;
Abstract
The present invention relates to a method of increasing biosimilarity of a TNF α binding protein to a reference TNF α binding protein by modifying the charge profile of the binding protein produced by cell culture in a cell culture medium, by making an adjustment to a cell culture condition The adjustment is an increase in the concentration of a metal ion in the cell culture medium and the adjustment occurs on one or more days during the cell culture method, whereby the adjustment in the cell culture condition results in the modification of the charge profile of the binding protein. The present invention also relates to a biosimilar protein obtainable by such a process.