logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11186647 B1

PDFFull Text
Date of Patent:
Nov. 30, 2021

Filed:

Feb. 04, 2021

Chimeric antigen receptors targeting bcma and methods of use thereof

Applicant:

Legend Biotech Usa Inc., Wilmington, DE (US);

Inventors:

Xiaohu Fan, Edmonton, CA;

Qiuchuan Zhuang, Jiangsu, CN;

Pingyan Wang, Anhui, CN;

Lin Wang, Jiangsu, CN;

Lei Yang, Anhui, CN;

Jiaying Hao, Jiangsu, CN;

Assignee:

LEGEND BIOTECH USA INC., Wilmington, DE (US);

Attorney:

Jones Day

Primary Examiner:

Brad Duffy

Int. Cl.
CPC ...
C07K 16/28 (2006.01); C07K 14/725 (2006.01); C07K 14/705 (2006.01); C07K 16/30 (2006.01); A61K 35/17 (2015.01); C12N 5/0783 (2010.01); C07K 19/00 (2006.01); C12N 5/10 (2006.01); C12N 15/62 (2006.01); C12N 15/63 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2878 (2013.01); A61K 35/17 (2013.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C07K 14/70575 (2013.01); C07K 14/70578 (2013.01); C07K 14/70596 (2013.01); C07K 16/2803 (2013.01); C07K 16/2887 (2013.01); C07K 16/2896 (2013.01); C07K 16/30 (2013.01); C07K 16/3061 (2013.01); C07K 19/00 (2013.01); C12N 5/0636 (2013.01); C12N 5/10 (2013.01); C12N 15/62 (2013.01); C12N 15/63 (2013.01); C07K 2317/22 (2013.01); C07K 2317/31 (2013.01); C07K 2317/35 (2013.01); C07K 2317/569 (2013.01); C07K 2317/622 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/21 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01); C12N 2510/00 (2013.01);
Abstract

The present application provides single-domain antibodies targeting BCMA, and chimeric antigen receptors (such as monovalent CAR, and multivalent CAR including bi-epitope CAR) comprising one or more anti-BCMA single-domain antibodies. Further provided are engineered immune effector cells (such as T cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating cancer are also provided.

Find Patent Forward Citations

Fan, Xiaohu. (2021). Chimeric antigen receptors targeting bcma and methods of use thereof (U.S. Patent No. 11186647). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11186647

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…