The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 30, 2021
Filed:
Apr. 20, 2018
Amgen Inc., Thousand Oaks, CA (US);
Ian Foltz, British Columbia, CA;
Shilpa Sambashivan, Menlo Park, CA (US);
Irwin Chen, Los Angeles, CA (US);
Susie Miki Harris, Newbury Park, CA (US);
Dora Toledo Warshaviak, Oak Park, CA (US);
Ian Driver, San Francisco, CA (US);
Daniel Lu, San Jose, CA (US);
AMGEN INC., Thousand Oaks, CA (US);
Abstract
The present invention relates to antigen binding proteins, such as monoclonal antibodies, that specifically bind to and activate human triggering receptor expressed on myeloid cells-2 (TREM2) and pharmaceutical compositions comprising such antigen binding proteins. The agonist antigen binding proteins (e.g. antibodies) of the invention are capable of activating TREM2/DAP12 signaling in myeloid cells in the absence of Fc-mediated cross-linking of the antigen binding proteins. Methods of treating or preventing conditions associated with TREM2 loss of function, such as Alzheimer's disease and multiple sclerosis, using the antigen binding proteins are also described.