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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11186632 B1

PDFFull Text
Date of Patent:
Nov. 30, 2021

Filed:

Aug. 15, 2017

Methods of treating cancer using bifunctional molecules that target growth factors

Applicants:

LI Mao, Pasadena, MD (US);

Hening Ren, Highland, MD (US);

Inventors:

Li Mao, Pasadena, MD (US);

Hening Ren, Highland, MD (US);

Assignee:

UNIVERSITY OF MARYLAND, BALTIMORE, Baltimore, MD (US);

Attorneys:

Wolter Van Dyke Davis, PLLC

Eugene J. Molinelli

Martha Cassidy

Primary Examiner:

Marianne P Allen

Int. Cl.
CPC ...
C07K 16/22 (2006.01); A61P 35/00 (2006.01); A61K 31/7068 (2006.01); A61K 38/17 (2006.01); A61K 39/395 (2006.01); C07K 14/71 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/22 (2013.01); A61K 31/7068 (2013.01); A61K 38/179 (2013.01); A61K 39/3955 (2013.01); A61P 35/00 (2018.01); C07K 14/71 (2013.01); A61K 2039/505 (2013.01); A61K 2039/54 (2013.01); A61K 2039/545 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2319/30 (2013.01); C07K 2319/32 (2013.01);
Abstract

This description provides novel strategies and methods for treatment of hyperproliferation conditions such as keloids, lung fibrosis, and lung cancer with the use of bi-functional molecules that target growth factors. A bifunctional hepatoma-derived growth factor (HDGF)-specific antibody for these methods comprises at least one complementarity determining region (CDR) specific for HDGF, at least one receptor domain that specifically binds to a growth factor selected from vascular endothelial growth factor (VEGF) and transforming growth factor beta (TGFβ).

Find Patent Forward Citations

Mao, Li. (2021). Methods of treating cancer using bifunctional molecules that target growth factors (U.S. Patent No. 11186632). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11186632

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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