The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 30, 2021

Filed:

Oct. 09, 2017
Applicants:

Integrated Biotherapeutics, Inc., Rockville, MD (US);

The University of Maryland, College Park, MD (US);

Inventors:

Mohammad Javad Aman, Rockville, MD (US);

Katie A. Howell, North Bethesda, MD (US);

Frederick Wayne Holtsberg, Taneytown, MD (US);

Xuelian Zhao, Gaithersburg, MD (US);

Yuxing Li, Boyds, MD (US);

Assignees:

INTEGRATED BIOTHERAPEUTICS, INC., Rockville, MD (US);

UNIVERSITY OF MARYLAND, COLLEGE PARK, College Park, MD (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/10 (2006.01); A61K 39/42 (2006.01); A61K 47/68 (2017.01); A61P 31/14 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/10 (2013.01); A61K 39/42 (2013.01); A61K 47/6841 (2017.08); A61K 2039/505 (2013.01); A61P 31/14 (2018.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/515 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C12N 2760/14011 (2013.01); C12N 2760/14022 (2013.01); C12N 2760/14111 (2013.01); C12N 2760/14122 (2013.01); C12N 2760/14211 (2013.01); C12N 2760/14222 (2013.01);
Abstract

This disclosure provides a method for preventing, treating, or managing an ebolavirus infection in a subject, where the method includes administering to a subject in need thereof an effective amount of at least one pan-ebolavirus internal fusion loop antibody or antigen-binding fragment thereof, wherein the binding domain specifically binds to the epitope on two or more ebolavirus species or strains.


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