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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11186624 B1

PDFFull Text
Expired
Date of Patent:
Nov. 30, 2021

Filed:

Sep. 23, 2016

Hbv antigen specific binding molecules and fragments thereof

Applicant:

Lion Tcr Pte. Ltd., Singapore, SG;

Inventors:

Antonio Bertoletti, Singapore, SG;

Tan Anthony Tanoto, Singapore, SG;

Sheau Fung Sarene Koh, Singapore, SG;

Zack Ho, Singapore, SG;

Assignee:

Lion TCR Pte. Ltd.;

Attorney:

Lerner, David, Littenberg, Krumholz & Mentlik, LLP

Primary Examiner:

Scott Long

Int. Cl.
CPC ...
C07K 14/725 (2006.01); C12Q 1/70 (2006.01); C07K 14/005 (2006.01); A61P 35/00 (2006.01); A61P 31/00 (2006.01); A61P 31/20 (2006.01); C12Q 1/6883 (2018.01); G01N 33/576 (2006.01); C12Q 1/6886 (2018.01); G01N 33/569 (2006.01); A61K 35/17 (2015.01); C12Q 1/6881 (2018.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); A61K 35/17 (2013.01); A61P 31/00 (2018.01); A61P 31/20 (2018.01); A61P 35/00 (2018.01); C07K 14/005 (2013.01); C12Q 1/6881 (2013.01); C12Q 1/6883 (2013.01); C12Q 1/6886 (2013.01); C12Q 1/706 (2013.01); G01N 33/56972 (2013.01); G01N 33/5761 (2013.01); A61K 38/00 (2013.01); C12N 2730/10122 (2013.01); C12N 2740/10043 (2013.01); C12N 2800/22 (2013.01); C12Q 2600/106 (2013.01); G01N 2333/7051 (2013.01);
Abstract

Hepatitis B Virus (HBV) antigen specific binding molecules, in particular T Cell Receptors (TCRs), TCR polypeptides and fragments thereof. The invention is also related to modified cells containing the TCRs, TCR polypeptides or fragments, pharmaceutical composition or kits including the same or methods of making or using the same as is described. In particular, the invention discloses TCRs or a fragments thereof, capable of binding to a peptide of a Hepatitis B Virus (HBV) Env polypeptide presented by an MHC class I molecule comprising an MHC class I σ-chain encoded by an HLA-Cw*08 allele.

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