The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 30, 2021
Filed:
Oct. 25, 2018
Shanghai Yao Yuan Biotechnology Co., Ltd., Shanghai, CN;
Tian Xu, Shanghai, CN;
Cong Xu, Shanghai, CN;
Danyang Liu, Shanghai, CN;
Jieqing Fan, Shanghai, CN;
Yanfang Pan, Shanghai, CN;
Tongruei Raymond Li, Shanghai, CN;
Xiaodong Chen, Shanghai, CN;
Shanghai Yao Yuan Biotechnology Co., Ltd., Shanghai, CN;
Abstract
The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A, A, L, L, L, Z, Z, W, W, R, R, R, R, R, Rand Rare defined herein.