The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 30, 2021
Filed:
Nov. 08, 2018
Novo Nordisk A/s, Bagsvaerd, DK;
Thomas Kruse, Herlev, DK;
Mikael Kofod-Hansen, Broenshoej, DK;
Martin Werner Borchsenius Muenzel, Broenshoej, DK;
Henning Thoegersen, Farum, DK;
Per Sauerberg, Farum, DK;
Jakob Ewald Rasmussen, Copenhagen, DK;
Carsten Behrens, Copenhagen, DK;
Thomas Hoeg-Jensen, Broenshoej, DK;
Vojtech Balsanek, Prague, CZ;
Zuzana Drobnakova, Prague, CZ;
Ladislav Droz, Prague, CZ;
Miroslav Havranek, Strancice, CZ;
Vladislav Kotek, Prague, CZ;
Milan Stengl, Klatovy, CZ;
Ivan Snajdr, Prague, CZ;
Hana Drusanova, Kromeriz, CZ;
Novo Nordisk A/S, Bagsvaerd, DK;
Abstract
This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates. The diboron compounds are characterized by formula (I), which is: R1-X—R2, and wherein 'X' is a mono- to multiatomic linker and where Rand R, which may be identical or different, each represents a group of Formula (11a) or (IIb) Also described are diboron conjugates represented by the general Formula (I'), which is: R1′-X′—R2′, in which either the moeities R1′ or R2′ or X′ carry a drug that is covalently attached to the diboron compound.