The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 30, 2021

Filed:

Dec. 01, 2017
Applicant:

Fraunhofer-gesellschaft Zur Forderung Der Angewandten Forschung E.v., Munich, DE;

Inventors:

Jan Potempa, Cracow, PL;

Sigrun Eick, Bolligen, CH;

Nadine Taudte, Halle, DE;

Jens-Ulrich Rahfeld, Seegebiet Mansfelder Land, DE;

Mirko Buchholz, Halle, DE;

Hans-Ulrich Demuth, Halle, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61P 31/04 (2006.01); A61K 9/00 (2006.01); C07D 491/20 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 9/0014 (2013.01); A61P 31/04 (2018.01); C07D 491/20 (2013.01);
Abstract

The present invention relates to bacterial glutaminyl cyclases and inhibitors thereof for use in the treatment of periodontitis and related conditions, and provides a bacterial glutaminyl cyclase (bacQC); an antibody which recognizes the bacQC, a method for identifying an inhibitor of the bacQC; a compound according to Formula (I); a pharmaceutical composition comprising a bacQC inhibitor compound; a bacQC inhibitor compound and/or a pharmaceutical composition for use in a method for treatment of the human or animal body, for use in a method for therapy or prophylaxis of a bacterial infection, and for use in a method for therapy and/or prophylaxis of an acute, chronic or recurrent periodontal disease.


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