The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 30, 2021
Filed:
May. 17, 2018
Applicant:
Selection Bioscience Llc, Shanghai, CN;
Inventors:
Assignee:
SELECTION BIOSCIENCE LLC, Shanghai, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 307/30 (2006.01); C07D 407/14 (2006.01); C07D 307/28 (2006.01); C07D 407/06 (2006.01); C07D 493/04 (2006.01);
U.S. Cl.
CPC ...
C07D 407/14 (2013.01); C07D 307/28 (2013.01); C07D 407/06 (2013.01); C07D 493/04 (2013.01);
Abstract
Disclosed are an intermediate of Eribulin and a preparation method therefor. In particular, disclosed are compounds as represented by formula II, formula III and formula V and a preparation method therefor. Ar is Calkyl substituted, alkyloxy substituted or unsubstituted aryl; Rand Ris an acetal protecting group or a thioacetal protecting group; Ris hydrogen or a hydroxyl protecting group; and X is halogen or a leaving group. The preparation method therefor has the advantages of mild reaction conditions, high selectivity, easy purification, low synthesis cost and the like, being suitable for large scale production.