The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 30, 2021
Filed:
Mar. 20, 2017
Applicant:
The Scripps Research Institute, La Jolla, CA (US);
Inventor:
Jin-Quan Yu, San Diego, CA (US);
Assignee:
The Scripps Research Institute, La Jolla, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07B 53/00 (2006.01); C07D 401/06 (2006.01); C07D 209/48 (2006.01); C07D 213/06 (2006.01); C07D 215/12 (2006.01); C07D 263/10 (2006.01); C07D 413/06 (2006.01); C07D 491/048 (2006.01); B01J 31/18 (2006.01);
U.S. Cl.
CPC ...
C07D 401/06 (2013.01); B01J 31/181 (2013.01); C07B 53/00 (2013.01); C07D 209/48 (2013.01); C07D 213/06 (2013.01); C07D 215/12 (2013.01); C07D 263/10 (2013.01); C07D 413/06 (2013.01); C07D 491/048 (2013.01); B01J 2531/004 (2013.01); B01J 2531/824 (2013.01); C07B 2200/07 (2013.01);
Abstract
Chiral acetyl-protected aminoethyl quinoline (APAQ), pyridine and imazoline ligands are disclosed that enable Pd (II)-catalyzed enantioselective arylation or heteroarylation of ubiquitous prochiral β-methylene C—H bonds of aliphatic amides offers an alternative disconnection for constructing β-chiral centers. Systematic tuning of the ligand structure reveals that a six-membered instead of a five-membered chelation of these types of ligands with the Pd(II) is important for accelerating the C(sp)-H activation thereby achieving enantioselectivity for quinoline and pyridine ligands.