The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 30, 2021
Filed:
Nov. 27, 2015
Applicant:
GE Healthcare As, Oslo, NO;
Inventors:
Mikkel Jacob Thaning, Oslo, NO;
Andreas Richard Meijer, Oslo, NO;
Assignee:
GE HEALTHCARE AS, Oslo, NO;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 49/10 (2006.01); C07D 257/02 (2006.01); A61K 49/18 (2006.01); A61K 47/54 (2017.01); A61K 49/00 (2006.01); A61K 31/28 (2006.01);
U.S. Cl.
CPC ...
C07D 257/02 (2013.01); A61K 47/547 (2017.08); A61K 49/0002 (2013.01); A61K 49/101 (2013.01); A61K 49/108 (2013.01); A61K 49/18 (2013.01); A61K 31/28 (2013.01); A61K 49/106 (2013.01);
Abstract
The present invention relates to a method of preparation of formulations of lanthanide metal complexes of macrocyclic chelators which further comprise a small excess of free chelator. The method uses a solid phase-bound scavenger chelator to remove excess lanthanide metal ions, prior to the addition of a defined excess chelator. Also provided is a method of preparation of MRI contrast agents, together with solid-phase bound chelator meglumine salts useful in the methods.