The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 30, 2021

Filed:

Nov. 21, 2018
Applicant:

Lawrence Livermore National Security, Llc, Livermore, CA (US);

Inventors:

Carlos A. Valdez, San Ramon, CA (US);

Nicholas A. Be, Oakland, CA (US);

Michael A. Malfatti, San Ramon, CA (US);

Heather Ann Enright, Livermore, CA (US);

Brian J. Bennion, Tracy, CA (US);

Timothy S. Carpenter, Livermore, CA (US);

Saphon Hok, Stockton, CA (US);

Hio Leong Lao, Livermore, CA (US);

Tuan H. Nguyen, Livermore, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 403/02 (2006.01); C07D 225/02 (2006.01); C07D 223/16 (2006.01); A61P 25/00 (2006.01); A61K 45/06 (2006.01); A61K 31/55 (2006.01);
U.S. Cl.
CPC ...
C07D 223/16 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); A61P 25/00 (2018.01);
Abstract

Described herein are oxime compounds capable of inactivating OP-based AChE inhibitors, crossing the blood brain barrier (BBB), and/or reactivation of OP-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more OP-based AChE inhibitors, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of OP-based AChE inhibitors for decontamination.


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