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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11186548 B1

PDFFull Text
Date of Patent:
Nov. 30, 2021

Filed:

Nov. 21, 2018

Compounds for central reactivation of organophosphorus-based compound-inhibited acetylcholinesterase and/or inactivation of organophosphorus-based acetylcholinesterase inhibitors and related compositions methods and systems for making and using them

Applicant:

Lawrence Livermore National Security, Llc, Livermore, CA (US);

Inventors:

Carlos A. Valdez, San Ramon, CA (US);

Nicholas A. Be, Oakland, CA (US);

Michael A. Malfatti, San Ramon, CA (US);

Heather Ann Enright, Livermore, CA (US);

Brian J. Bennion, Tracy, CA (US);

Timothy S. Carpenter, Livermore, CA (US);

Saphon Hok, Stockton, CA (US);

Hio Leong Lao, Livermore, CA (US);

Tuan H. Nguyen, Livermore, CA (US);

Assignee:

LAWRENCE LIVERMORE NATIONAL SECURITY, LLC, Livermore, CA (US);

Attorney:

Steinfl + Bruno LLP

Primary Examiner:

Bruck Kifle

Int. Cl.
CPC ...
C07D 403/02 (2006.01); C07D 225/02 (2006.01); C07D 223/16 (2006.01); A61P 25/00 (2006.01); A61K 45/06 (2006.01); A61K 31/55 (2006.01);
U.S. Cl.
CPC ...
C07D 223/16 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); A61P 25/00 (2018.01);
Abstract

Described herein are oxime compounds capable of inactivating OP-based AChE inhibitors, crossing the blood brain barrier (BBB), and/or reactivation of OP-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more OP-based AChE inhibitors, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of OP-based AChE inhibitors for decontamination.

Find Patent Forward Citations

Quick Actions:

Valdez, Carlos. (2021). Compounds for central reactivation of organophosphorus-based compound-inhibited acetylcholinesterase and/or inactivation of organophosphorus-based acetylcholinesterase inhibitors and related compositions methods and systems for making and using them (U.S. Patent No. 11186548). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11186548

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