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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11185576 B1

PDFFull Text
Date of Patent:
Nov. 30, 2021

Filed:

Mar. 14, 2019

Flexible tissue matrix and methods for joint repair

Applicant:

Isto Technologies Ii, Llc, Hopkinton, MA (US);

Inventors:

Mitchell S. Seyedin, St. Louis, MO (US);

Anthony J. Ward, St. Louis, MO (US);

Matthew Matava, Chesterfield, MO (US);

Assignee:

Isto Technologies II, LLC, Chicago, IL (US);

Attorney:

Polsinelli PC

Primary Examiner:

Arthur S Leonard

Int. Cl.
CPC ...
A61K 35/28 (2015.01); A61L 27/26 (2006.01); A61L 27/56 (2006.01); A61K 38/51 (2006.01); A61K 38/18 (2006.01); A61K 38/19 (2006.01); A61K 38/20 (2006.01); A61K 38/30 (2006.01); A61K 38/39 (2006.01); A61L 27/52 (2006.01); A61L 27/58 (2006.01); A61K 38/48 (2006.01);
U.S. Cl.
CPC ...
A61K 38/51 (2013.01); A61K 38/18 (2013.01); A61K 38/1825 (2013.01); A61K 38/1841 (2013.01); A61K 38/1858 (2013.01); A61K 38/1875 (2013.01); A61K 38/193 (2013.01); A61K 38/20 (2013.01); A61K 38/30 (2013.01); A61K 38/39 (2013.01); A61K 38/4886 (2013.01); A61L 27/26 (2013.01); A61L 27/52 (2013.01); A61L 27/56 (2013.01); A61L 27/58 (2013.01);
Abstract

A synthetic, flexible tissue matrix and methods for repairing hyaline cartilage defects in a joint using the flexible tissue matrix are described. The flexible tissue matrix includes a high molecular weight polycaprolactone polymer entangled with a polysaccharide such as hyaluronic acid. In the methods, autologous bone mesenchymal stem cells are introduced to a joint by a microfracturing technique, and a membrane made of the flexible matrix is applied to the joint. Cartilage which forms in the joint is hyaline cartilage rather than fibrocartilage.

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