The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 30, 2021
Filed:
Dec. 02, 2016
Applicant:
Massachusetts Eye & Ear Infirmary, Boston, MA (US);
Inventors:
Albert Edge, Brookline, MA (US);
Yenfu Cheng, Boston, MA (US);
Assignee:
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4439 (2006.01); A61K 38/00 (2006.01); C07D 401/04 (2006.01); C07D 487/04 (2006.01); C07D 405/14 (2006.01); A61K 31/437 (2006.01); C07D 413/14 (2006.01); C12Q 1/48 (2006.01); C07D 403/04 (2006.01); A61P 27/16 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4439 (2013.01); A61K 9/0046 (2013.01); A61K 31/437 (2013.01); A61K 38/00 (2013.01); A61P 27/16 (2018.01); C07D 401/04 (2013.01); C07D 403/04 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 487/04 (2013.01); C12Q 1/485 (2013.01); G01N 2800/14 (2013.01);
Abstract
Methods for treating hearing loss that include administering an inhibitor, e.g., a small molecule inhibitor, of casein kinase 1, preferably in combination with a treatment that stimulates Atoh1 gene expression, e.g., a gamma-secretase inhibitor, an Atoh1 stimulatory compound, or a GSK-3-beta inhibitor.