The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 23, 2021

Filed:

Apr. 07, 2017
Applicant:

Eth Zurich, Zurich, CH;

Inventors:

Markus Aebi, Wettingen, CH;

Markus Kunzler, Neuenhof, CH;

Jorn Piel, Zurich, CH;

Michael Freeman, Feeding Hills, MA (US);

Niels Van Der Velden, Houten, NL;

Noemi Kalin, Emmenbrucke, CH;

Assignee:

ETH ZURICH, Zurich, CH;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/10 (2006.01); C07K 16/00 (2006.01); C07K 14/375 (2006.01); C07K 16/40 (2006.01); C12P 21/02 (2006.01);
U.S. Cl.
CPC ...
C12N 9/1007 (2013.01); C07K 14/375 (2013.01); C07K 16/00 (2013.01); C07K 16/40 (2013.01); C12P 21/02 (2013.01); C12Y 201/01049 (2013.01); C07K 2319/00 (2013.01); C07K 2319/21 (2013.01); C07K 2319/50 (2013.01);
Abstract

The present invention is directed to all aspects of novel methyl transferase enzymes that methylate backbone amides of (poly)peptides. The present invention also relates to nucleic acids encoding these enzymes as well as corresponding vectors and host cells comprising these. Moreover, the present invention encompasses the use of said enzymes for modifying (poly)peptides as well as corresponding methods. Also, the present invention pertains to further novel enzymes for modifying (poly)peptides derived from the omphalotin gene cluster ofand the homologous gene clusters fromandas well as related aspects.


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