The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 23, 2021
Filed:
Dec. 07, 2017
Applicant:
David Gordon Bermudes, Woodland Hills, CA (US);
Inventor:
David Gordon Bermudes, Woodland Hills, CA (US);
Assignee:
Other;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/112 (2006.01); A61K 39/108 (2006.01); A61K 39/02 (2006.01); A61K 39/00 (2006.01); C12N 15/74 (2006.01); C07K 14/325 (2006.01); A61P 35/00 (2006.01); C12N 15/62 (2006.01); C07K 14/81 (2006.01); A61K 38/00 (2006.01); A61K 39/10 (2006.01);
U.S. Cl.
CPC ...
C07K 14/325 (2013.01); A61K 39/0258 (2013.01); A61K 39/0275 (2013.01); A61P 35/00 (2018.01); C07K 14/81 (2013.01); C12N 15/625 (2013.01); C12N 15/74 (2013.01); A61K 38/00 (2013.01); A61K 39/099 (2013.01); A61K 2039/10 (2013.01); A61K 2039/522 (2013.01); C07K 2319/03 (2013.01); C07K 2319/33 (2013.01); C07K 2319/55 (2013.01);
Abstract
Bacteria with tumor-targeting capability express, surface displayed, secreted and/or released modified chimeric therapeutic proteins with enhanced therapeutic activity against a neoplastic tissue including solid tumors, lymphomas and leukemias. The bacteria may also express, surface display, secrete and/or release a tumor-penetrating peptide. The bacteria may be attenuated, non-pathogenic, low pathogenic or a probiotic. The chimeric proteins may be protease sensitive and may optionally be further accompanied by co-expression of a secreted protease inhibitor as a separate molecule or as a fusion.