The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 23, 2021

Filed:

Nov. 07, 2017
Applicant:

Cyclerion Therapeutics, Inc., Cambridge, MA (US);

Inventors:

Glen Robert Rennie, Somerville, MA (US);

Timothy Claude Barden, Salem, MA (US);

Thomas Wai-Ho Lee, Lexington, MA (US);

Rajesh R. Iyengar, West Newton, MA (US);

Takashi Nakai, Newton, MA (US);

Ara Mermerian, Waltham, MA (US);

Lei Jia, Belmont, MA (US);

Karthik Iyer, Cambridge, MA (US);

G-Yoon Jamie Im, Cambridge, MA (US);

Paul Allan Renhowe, Sudbury, MA (US);

Joon Jung, Newton, MA (US);

Peter Germano, Newton, MA (US);

Kim Tang, Belmont, MA (US);

Assignee:

Cyclerion Therapeutics, Inc., Cambridge, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 487/04 (2013.01);
Abstract

The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) and/or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP) might be desirable. Various compounds are disclosed, including those of Formula (I).


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