The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 23, 2021
Filed:
Mar. 29, 2017
University of Virginia Patent Foundation, Charlottesville, VA (US);
Virginia Tech Intellectual Properties, Inc., Blacksburg, VA (US);
Steven Brandon Thorpe, Palmyra, VA (US);
Webster L. Santos, Blacksburg, VA (US);
Kevin R. Lynch, Charlottesville, VA (US);
U niversity of Virginia Patent Foundation, Charlottesville, VA (US);
Virginia Tech Entellectuzal Properties, Inc., Blacksburg, VA (US);
Abstract
Sphingosine kinases are enzymes that catalyze the biosynthesis of sphingosine-1-phosphate. The invention provides prodrugs of compounds that are effective for inhibition of sphingosine kinase type 1, sphingosine kinase type 2, or both, according to formula (I) as described herein. Formula I compounds are useful in the treatment of a range of diseases wherein increasing the level of sphingosine-1-phosphate in blood is medically indicated. The invention also provides pharmaceutical compositions of Formula I compounds.