The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 23, 2021

Filed:

Jun. 17, 2020
Applicants:

Cfd Research Corporation, Huntsville, AL (US);

The Board of Regents of the University of Oklahoma, Norman, OK (US);

Inventors:

Anuj Singhal, Huntsville, AL (US);

Robert H. Cichewicz, Norman, OK (US);

Lin Du, Norman, OK (US);

JianLan You, Forest Hills, NY (US);

Hanumantha Rao Paritala, Madison, AL (US);

Abigail Grace Edwards, Hazel Green, AL (US);

Assignees:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 209/30 (2006.01); A61K 47/60 (2017.01); A01N 43/38 (2006.01); C07D 417/12 (2006.01); A01N 55/00 (2006.01); C07D 401/12 (2006.01); A01N 43/40 (2006.01); C07D 471/04 (2006.01); C07F 7/18 (2006.01); A01N 43/90 (2006.01); A61K 47/54 (2017.01); A01N 25/08 (2006.01);
U.S. Cl.
CPC ...
C07D 209/30 (2013.01); A01N 25/08 (2013.01); A01N 43/38 (2013.01); A01N 43/40 (2013.01); A01N 43/90 (2013.01); A01N 55/00 (2013.01); A61K 47/54 (2017.08); A61K 47/545 (2017.08); A61K 47/60 (2017.08); C07D 401/12 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07F 7/1804 (2013.01);
Abstract

A method of selectively inhibiting pathogenic microbes includes: providing a compound that is functional as a selective antimicrobial having a structure of Formula 1, or derivative thereof, salt thereof, or stereoisomer thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combination thereof; and contacting a pathogenic microbe with the compound such that the pathogenic microbe is selectively inhibited; wherein: ring A is a cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or polycycle combination thereof; X is S, SO, or SO; Y is a linker or bond; Z is CH, CR, or N; Zis C or N to form an imidazopyridine; each Z, Z, or Zis independently CH, CR, or N; each Zor Zis C or CH; each R, R, Rand/or Ris independently a substituent; m is 0, 1, 2, 3, or 4; and n is zero or a positive integer.


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