The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 23, 2021
Filed:
Aug. 13, 2013
Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof
Applicant:
David Ayares, Blacksburg, VA (US);
Inventor:
David Ayares, Blacksburg, VA (US);
Assignee:
Revivicor, Inc., Blacksburg, VA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61L 27/36 (2006.01); A01K 67/027 (2006.01); C12N 15/85 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61L 27/3604 (2013.01); A01K 67/0271 (2013.01); A01K 67/0275 (2013.01); A01K 67/0278 (2013.01); A61K 45/06 (2013.01); C12N 15/8509 (2013.01); A01K 2217/052 (2013.01); A01K 2217/075 (2013.01); A01K 2227/108 (2013.01); A01K 2267/02 (2013.01);
Abstract
The present invention provides certain donor animals, tissues and cells that are particularly useful for xenotransplantation therapies. In particular, the invention includes porcine animals, as well as tissue and cells derived from these, which lack any expression of functional alpha 1,3 galactosyltransferase (aGT) and express one or more additional transgenes which make these animals suitable donors for xenotransplantation of vascularized xenografts and derivatives thereof. Methods of treatment and using organs, tissues and cells derived from such animals are also provided.