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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11179494 B1

PDFFull Text
Date of Patent:
Nov. 23, 2021

Filed:

Dec. 15, 2015

Collagenous tissue repair device

Applicant:

Northeastern University, Boston, MA (US);

Inventors:

Jeffrey A. Paten, Hyde Park, MA (US);

Jeffrey W. Ruberti, Lexington, MA (US);

Assignee:

Northeastern University, Boston, MA (US);

Attorney:

Verrill Dana, LLP

Primary Examiner:

Valerie L Woodward

Int. Cl.
CPC ...
A61L 27/24 (2006.01); A61M 5/142 (2006.01); A61K 38/39 (2006.01); A61K 47/18 (2017.01); A61K 9/00 (2006.01); A61K 38/48 (2006.01); A61K 38/47 (2006.01); A61H 1/00 (2006.01); A61H 1/02 (2006.01); A61L 27/50 (2006.01); A61L 27/54 (2006.01); D01D 5/00 (2006.01); D01F 4/00 (2006.01); A61M 5/14 (2006.01); A61N 1/04 (2006.01);
U.S. Cl.
CPC ...
A61L 27/24 (2013.01); A61H 1/008 (2013.01); A61H 1/02 (2013.01); A61K 9/0019 (2013.01); A61K 38/39 (2013.01); A61K 38/47 (2013.01); A61K 38/4873 (2013.01); A61K 38/4886 (2013.01); A61K 47/183 (2013.01); A61L 27/50 (2013.01); A61L 27/54 (2013.01); A61M 5/142 (2013.01); C12Y 302/01035 (2013.01); C12Y 304/22001 (2013.01); C12Y 304/24 (2013.01); C12Y 304/24007 (2013.01); D01D 5/00 (2013.01); D01F 4/00 (2013.01); A61L 2300/41 (2013.01); A61L 2300/426 (2013.01); A61L 2400/06 (2013.01); A61L 2430/10 (2013.01); A61M 5/14 (2013.01); A61M 5/14248 (2013.01); A61M 2202/095 (2013.01); A61M 2205/50 (2013.01); A61N 1/0456 (2013.01); D10B 2509/00 (2013.01);
Abstract

Methods and devices for tissue remodeling and repair of collagenous tissues, including tendons, ligaments, and bone, as well as scalable connective tissue manufacturing, are provided. Collagen fibers are assembled by extensional strain-induced flow crystallization of collagen monomers. Extensional strain also drives the fusion of already formed short collagen fibrils to produce long-range, continuous fibers. Wearable devices for controlled tissue remodeling and wound healing deliver a tissue remodeling solution to a tissue repair site. The remodeling solution, together with appropriate application of strain to the tissue remodeling site, accelerate healing, prevent injury, and reduce scar formation.

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