The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 23, 2021
Filed:
Dec. 08, 2020
Applicant:
Animatus Biosciences, Llc, Houston, TX (US);
Inventors:
Assignee:
ANIMATUS BIOSCIENCES, LLC, Houston, TX (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/88 (2006.01); A61K 9/10 (2006.01); A61K 48/00 (2006.01); C12N 5/077 (2010.01); A61P 9/10 (2006.01); A61P 9/04 (2006.01);
U.S. Cl.
CPC ...
A61K 48/005 (2013.01); A61K 48/0075 (2013.01); A61P 9/04 (2018.01); A61P 9/10 (2018.01); C12N 5/0657 (2013.01); C12N 15/88 (2013.01); C12N 2510/00 (2013.01);
Abstract
Compositions and methods for promoting adult mammalian cardiomyocytes processes and systems for enhancing cardiomyocyte regeneration are described. The invention relates to locally administering a therapeutic agent containing a modified messenger RNA for expressing a mutated serum response factor polypeptide and a modified messenger RNA for expressing a mutated YAP polypeptide into diseased heart muscle to promote cardiomyocyte proliferation and cardiac regeneration.