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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11179394 B1

PDFFull Text
Expired
Date of Patent:
Nov. 23, 2021

Filed:

Jun. 17, 2015

Method for treating cancer using a combination of chk1 and atr inhibitors

Applicant:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Inventors:

Thomas Helleday, Stockholm, SE;

Kumar Sanjiv, Stockholm, SE;

Assignee:

VERTEX PHARMACEUTICALS INCORPORATED, Boston, MA (US);

Attorneys:

Dechert LLP

Andrea L. C. Reid

Danielle M. Nihan

Primary Examiner:

Jeffrey S Lundgren

Assistant Examiner:

Chris E Simmons

Int. Cl.
CPC ...
A61P 35/00 (2006.01); A61K 31/519 (2006.01); A61K 31/4535 (2006.01); A61K 45/06 (2006.01); A61K 31/497 (2006.01); A61K 31/5377 (2006.01); A61K 31/4709 (2006.01); A61K 31/551 (2006.01); A61N 5/10 (2006.01); A61K 31/4985 (2006.01); A61K 31/4965 (2006.01);
U.S. Cl.
CPC ...
A61K 31/519 (2013.01); A61K 31/4535 (2013.01); A61K 31/4709 (2013.01); A61K 31/497 (2013.01); A61K 31/4965 (2013.01); A61K 31/4985 (2013.01); A61K 31/5377 (2013.01); A61K 31/551 (2013.01); A61K 45/06 (2013.01); A61N 5/10 (2013.01);
Abstract

The present invention relates to methods of treating cancer in a patient by administering a compound useful as an inhibitor of ATR protein kinase in combination with a compound useful as an inhibitor of Chk1 protein kinase. The aforementioned combination displays a surprising synergistic effect in treating cancer despite the targeted protein kinases being within the same biological pathway. Moreover, the present invention also relates to methods of treating cancer by administering a compound useful as an inhibitor of ATR protein kinase; administering a compound useful as an inhibitor of Chk1 protein kinase; as well as administering a DNA damaging agent to a patient. The compounds utilized in this invention are represented by formula I and formula II: wherein the variables are as defined herein.

Find Patent Forward Citations

Helleday, Thomas. (2021). Method for treating cancer using a combination of chk1 and atr inhibitors (U.S. Patent No. 11179394). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11179394

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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