The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 23, 2021
Filed:
Mar. 14, 2016
Applicant:
University of Dundee, Dundee, GB;
Inventors:
Assignee:
University of Dundee, Dundee, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/426 (2006.01); A61K 31/4025 (2006.01); A61K 31/4196 (2006.01); A61K 31/381 (2006.01); A61K 31/551 (2006.01); A61K 31/16 (2006.01); C07D 417/14 (2006.01); C07D 417/12 (2006.01); C07D 487/04 (2006.01); C07D 495/14 (2006.01);
U.S. Cl.
CPC ...
A61K 31/426 (2013.01); A61K 31/16 (2013.01); A61K 31/381 (2013.01); A61K 31/4025 (2013.01); A61K 31/4196 (2013.01); A61K 31/551 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 487/04 (2013.01); C07D 495/14 (2013.01);
Abstract
There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, having utility in PROteolysis Targeted Chimeras (PROTACs), as well as processes for the preparation thereof, and use in medicine. There is particularly provided PROTACs which bind to a protein within the bromo- and Extra-terminal (BET) family of proteins, and especially to PROTACs including novel small molecule E3 ubiquitin ligase protein binding ligand compounds which selectively induce degradation of the BRD4 protein within the bromodomain of the BET family of proteins.