The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 23, 2021

Filed:

Feb. 02, 2018
Applicant:

City of Hope, Duarte, CA (US);

Inventors:

Samuel Rahbar, Beverly Hills, CA (US);

Timothy W. Synold, Monrovia, CA (US);

John Termini, Altadena, CA (US);

Gerald Wuenschell, Duarte, CA (US);

Daniel Tamae, Duarte, CA (US);

Assignee:

CITY OF HOPE, Duarte, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 30/72 (2006.01); A61P 3/10 (2006.01); A61K 31/195 (2006.01); G01N 33/68 (2006.01); G01N 30/88 (2006.01); A61N 5/10 (2006.01); A61K 45/06 (2006.01); G01N 30/04 (2006.01); A61K 31/121 (2006.01);
U.S. Cl.
CPC ...
A61K 31/195 (2013.01); A61P 3/10 (2018.01); G01N 30/7233 (2013.01); G01N 30/7266 (2013.01); G01N 33/6893 (2013.01); A61K 31/121 (2013.01); A61K 45/06 (2013.01); A61N 5/10 (2013.01); G01N 2030/045 (2013.01); G01N 2030/8827 (2013.01); G01N 2030/8868 (2013.01); G01N 2800/042 (2013.01); G01N 2800/56 (2013.01);
Abstract

Methods of quantifying a N-(1-carboxyethyl)-2'-deoxyguanosine (CEdG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of metabolic disorders or complications associated therewith, including diabetes, its associated complications, and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG levels before and after treatment. Measurement of CEdG levels is achieved by using liquid chromatography electrospray ionization tandem mass spectrometry.


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