The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 23, 2021

Filed:

Feb. 12, 2016
Applicant:

Signature Therapeutics, Inc., Palo Alto, CA (US);

Inventors:

Thomas E. Jenkins, Half Moon Bay, CA (US);

Craig O. Husfeld, San Mateo, CA (US);

Julie D. Seroogy, San Carlos, CA (US);

Jonathan W. Wray, San Francisco, CA (US);

Assignee:

Signature Therapeutics, Inc., Palo Alto, CA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/165 (2006.01); A61K 9/00 (2006.01); A61K 31/24 (2006.01); C07C 279/14 (2006.01); A61K 31/16 (2006.01); C07C 237/22 (2006.01); A61K 45/06 (2006.01); A61K 47/54 (2017.01);
U.S. Cl.
CPC ...
A61K 31/165 (2013.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 31/16 (2013.01); A61K 31/24 (2013.01); A61K 45/06 (2013.01); A61K 47/542 (2017.08); A61K 47/543 (2017.08); C07C 237/22 (2013.01); C07C 279/14 (2013.01);
Abstract

Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise an amphetamine prodrug that provides enzymatically-controlled release of amphetamine or an amphetamine analog. The composition can further comprise an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of amphetamine or the amphetamine analog from the amphetamine prodrug so as to attenuate enzymatic cleavage of the amphetamine prodrug.


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