The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 16, 2021

Filed:

Jan. 14, 2019
Applicant:

Applied Biosystems, Llc, Carlsbad, CA (US);

Inventors:

Mark F. Oldham, Emerald Hills, CA (US);

Eric S. Nordman, Palo Alto, CA (US);

Assignee:

Applied Biosystems, LLC, Carlsbad, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 27/414 (2006.01); B82Y 15/00 (2011.01); C12Q 1/6825 (2018.01); G01N 33/543 (2006.01);
U.S. Cl.
CPC ...
G01N 27/4145 (2013.01); B82Y 15/00 (2013.01); C12Q 1/6825 (2013.01); G01N 27/4146 (2013.01); G01N 33/54373 (2013.01);
Abstract

There is disclosed a system for electrical charge detection comprising a nanoFET device. Also disclosed is a method of electrical charge detection for single molecule sequencing. The method includes attaching a macromolecule or assemblies thereof to a gate of a nanoFET device and flowing in a solution of charge tags, where a charge tag includes a nucleotide attached to a charge complex. The method also includes incorporating one charge tag into the macromolecule or assemblies thereof and cleaving the charge tags from the macromolecule or assemblies thereof. The method further includes detecting at least one of current and voltage from the nanoFET device.


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