The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 16, 2021
Filed:
Nov. 10, 2016
Applicants:
B. G. Negev Technologies and Applications Ltd., AT Ben-gurion University, Beer Sheva, IL;
The National Institute for Biotechnology IN the Negev Ltd., Beer Sheva, IL;
Inventor:
Varda Shoshan-Barmatz, Omer, IL;
Assignees:
B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN- GURION UNIVERSITY, Beer Sheva, IL;
THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD., Beer Sheva, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/113 (2010.01); C12Q 1/68 (2018.01); C12Q 1/6886 (2018.01); A61K 31/713 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1138 (2013.01); A61K 31/713 (2013.01); A61P 35/00 (2018.01); C12Q 1/68 (2013.01); C12Q 1/6886 (2013.01); C12N 2310/14 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/158 (2013.01);
Abstract
Provided are RNA inhibitory molecules, particularly siRNA molecules silencing the expression of Voltage-Dependent Ion Chanel-1 (VDAC1) for the induction of cancer stem cell differentiation and reduction of TAMs abundance and tumor angiogenesis, thereby preventing tumor invention and recurrence.