The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 16, 2021
Filed:
Oct. 19, 2017
The Scripps Research Institute, La Jolla, CA (US);
Travis S. Young, La Jolla, CA (US);
Leonard Presta, La Jolla, CA (US);
David Rodgers, La Jolla, CA (US);
Eric Hampton, La Jolla, CA (US);
Timothy Wright, La Jolla, CA (US);
Peter G. Schultz, La Jolla, CA (US);
Eduardo Laborda, La Jolla, CA (US);
Elvira Khialeeva, La Jolla, CA (US);
Sophie Viaud, La Jolla, CA (US);
The Scripps Research Institute, La Jolla, CA (US);
Abstract
The present disclosure provides compositions, methods, kits, and platforms for selectively activating and deactivating chimeric receptor effector cells using humanized chimeric receptor effector cell switches that comprise a humanized targeting moiety that binds CD19 on a target cell and a chimeric receptor interacting domain that binds to a chimeric receptor effector cell and/or chimeric receptor effector cell switches comprising optimized chimeric receptor interacting domains. Also disclosed are methods of treating disease and conditions with such chimeric receptor effector cells and chimeric receptor effector cell switches.