The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 16, 2021
Filed:
May. 15, 2018
Applicants:
University of Houston System, Houston, TX (US);
Trustees of Tufts College, Medford, MA (US);
Inventors:
Gregory Cuny, Houston, TX (US);
Sameer Nikhar, Houston, TX (US);
Alexei Degterev, Brookline, MA (US);
Assignees:
UNIVERSITY OF HOUSTON SYSTEM, Houston, TX (US);
TRUSTEES OF TUFTS COLLEGE, Medford, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4375 (2006.01); A61K 31/472 (2006.01); A61K 31/4725 (2006.01); A61K 31/517 (2006.01); A61K 31/519 (2006.01); A61P 9/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); C07D 217/22 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01);
Abstract
Identified compounds demonstrate protein kinase inhibitory activity. More specifically, the compounds having the structures below (I) are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin-like kinase 2 (ALK2). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 could provide therapeutic benefit.