The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 16, 2021

Filed:

Apr. 24, 2017
Applicant:

Purdue Research Foundation, West Lafayette, IN (US);

Inventors:

Cagri A. Savran, West Lafayette, IN (US);

Chun-Li Chang, West Lafayette, IN (US);

Wanfeng Huang, San Jose, CA (US);

Onur Gur, West Lafayette, IN (US);

Rohil Jain, West Lafayette, IN (US);

Assignee:

Purdue Research Foundation, West Lafayette, IN (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); B03C 1/01 (2006.01); B03C 1/033 (2006.01); B03C 1/28 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502761 (2013.01); B03C 1/01 (2013.01); B03C 1/0332 (2013.01); B03C 1/0335 (2013.01); B03C 1/288 (2013.01); B01L 2200/0652 (2013.01); B01L 2200/0668 (2013.01); B01L 2200/0673 (2013.01); B01L 2200/0689 (2013.01); B01L 2300/0627 (2013.01); B01L 2300/0803 (2013.01); B01L 2300/0819 (2013.01); B01L 2300/0851 (2013.01); B01L 2400/043 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/086 (2013.01); B03C 2201/18 (2013.01); B03C 2201/26 (2013.01);
Abstract

Microfluidic systems and methods are described for capturing magnetic target entities bound to one or more magnetic beads. The systems include a well array device that includes a substrate with a surface that has a plurality of wells arranged in one or more arrays on the surface. A first array of wells is arranged adjacent to a first location on the surface. A second and subsequent arrays, if present, are arranged sequentially on the surface at second and subsequent locations. When a liquid sample is added onto the substrate and caused to flow, the liquid sample will flow across the first array first and then flow across the second and subsequent arrays in sequential order. The wells in the first array each have a size that permits entry of only one target entity into the well and each well in the first array has approximately the same size.


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