The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 16, 2021

Filed:

May. 04, 2015
Applicant:

Takeda Gmbh, Constance, DE;

Inventors:

Willow Diluzio, Westford, MA (US);

Phuong Nguyen, Burlingame, CA (US);

Assignee:

Takeda GmbH, Constance, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 47/26 (2006.01); A61K 9/08 (2006.01); C07K 16/24 (2006.01); A61K 47/10 (2017.01); A61K 38/00 (2006.01); A61K 47/18 (2017.01); A61K 47/22 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39591 (2013.01); A61K 9/08 (2013.01); A61K 38/00 (2013.01); A61K 47/10 (2013.01); A61K 47/183 (2013.01); A61K 47/22 (2013.01); A61K 47/26 (2013.01); C07K 16/243 (2013.01); C07K 2317/21 (2013.01); C07K 2317/76 (2013.01);
Abstract

The present invention relates to aqueous formulations comprising a compound neutralizing GM-CSF in concentrations of at least 20 mg/ml, a tonicity modifier, a buffer and one or more of surfactants, amino acids, antioxidants and/or chelators, wherein the composition is stable. The ingredients of the formulation preferably provide stability to the compound neutralizing GM-CSF in view of long-term storage. In a preferred aspect, the formulation is for use in therapy, preferably for use in the treatment of inflammatory and autoimmune disorders, preferably including allergic and psoriatic disorders, as well as arthritic and asthmatic disorders.


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