The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 16, 2021
Filed:
Mar. 17, 2014
Applicant:
Sementis Limited, Berwick, AU;
Inventor:
Paul Michael Howley, Berwick, AU;
Assignee:
Sementis Limited, Berwick, AU;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/35 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/35 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); A61K 2039/515 (2013.01); A61K 2039/5154 (2013.01); A61K 2039/572 (2013.01); C07K 2319/95 (2013.01); C12N 2710/24134 (2013.01); C12N 2710/24142 (2013.01); C12N 2710/24143 (2013.01); C12N 2710/24171 (2013.01);
Abstract
The present invention relates to a poxvirus vector comprising a nucleic acid sequence encoding a fusion protein comprising: (i) a peanut allergen selected from list consisting of at least two peanut allergens from ara h 1, ara h 2, ara h 3, ara h 4, ara h 5, ara h 6. ara h 7, ara h 8, ara h 9, ara h I O and ara h I I or a derivative or part thereof having at least 70% sequence identity thereto, and (ii) a profeasome degradation tag to enhance intracellular degradation of the fusion protein. Methods of desensitizing or inducing tolerance to a peanut allergen and/or suppressing an allergic response to a peanut allergen are also disclosed.