The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 16, 2021
Filed:
May. 16, 2018
Translate Bio, Inc., Lexington, MA (US);
Michael Heartlein, Lexington, MA (US);
Frank DeRosa, Lexington, MA (US);
Alan Kimura, Lexington, MA (US);
Jonathan Abysalh, Lexington, MA (US);
Anusha Dias, Lexington, MA (US);
Shrirang Karve, Lexington, MA (US);
Zarna Patel, Lexington, MA (US);
TRANSLATE BIO, INC., Lexington, MA (US);
Abstract
The present invention provides, among other things, methods of treating cystic fibrosis, comprising a step of administering to a subject in need of treatment a composition comprising an mRNA encoding a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, wherein the mRNA encoding the CFTR protein comprises a polynucleotide sequence at least 80% identical to SEQ ID NO: 1, wherein the mRNA is at a concentration of at least 0.4 mg/mL, and wherein the step of administering comprises inhalation.