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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11173190 B1

PDFFull Text
Date of Patent:
Nov. 16, 2021

Filed:

May. 16, 2018

Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding cftr

Applicant:

Translate Bio, Inc., Lexington, MA (US);

Inventors:

Michael Heartlein, Lexington, MA (US);

Frank DeRosa, Lexington, MA (US);

Alan Kimura, Lexington, MA (US);

Jonathan Abysalh, Lexington, MA (US);

Anusha Dias, Lexington, MA (US);

Shrirang Karve, Lexington, MA (US);

Zarna Patel, Lexington, MA (US);

Assignee:

TRANSLATE BIO, INC., Lexington, MA (US);

Attorneys:

Proskauer Rose LLP

Fangli Chen

Primary Examiner:

J E Angell

Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 38/17 (2006.01); A61P 11/12 (2006.01); A61K 9/127 (2006.01); A61K 9/00 (2006.01); C12N 15/88 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1709 (2013.01); A61K 9/0078 (2013.01); A61K 9/127 (2013.01); A61K 48/0075 (2013.01); A61P 11/12 (2018.01); C12N 15/88 (2013.01);
Abstract

The present invention provides, among other things, methods of treating cystic fibrosis, comprising a step of administering to a subject in need of treatment a composition comprising an mRNA encoding a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, wherein the mRNA encoding the CFTR protein comprises a polynucleotide sequence at least 80% identical to SEQ ID NO: 1, wherein the mRNA is at a concentration of at least 0.4 mg/mL, and wherein the step of administering comprises inhalation.

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Heartlein, Michael. (2021). Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding cftr (U.S. Patent No. 11173190). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11173190

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