The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 09, 2021

Filed:

Jul. 24, 2018
Applicants:

Albert Einstein Collge of Medicine, Bronx, NY (US);

King's College London, London, GB;

Inventors:

John Condeelis, Bronx, NY (US);

Tony Tsz-Cheong Ng, London, GB;

Gregory Weitsman, London, GB;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/574 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
G01N 33/57415 (2013.01); C07K 16/2896 (2013.01); G01N 33/57496 (2013.01); G01N 2440/14 (2013.01); G01N 2800/56 (2013.01);
Abstract

Methods and products are provided for determining if a subject having a tumor is at risk of metastasis of the tumor. Specifically, the methods comprise detecting phosphorylated cofilin, and both phosphorylated and non-phosphorylated cofilin; quantifying the phosphorylated cofilin, and the total of phosphorylated and nonphosphorylated cofilin; and determining if a subject having the tumor is likely to experience metastasis of the tumor, based on the ratio of the amount of detected phosphorylated cofilin:total amount of phosphorylated and non-phosphorylated cofilin detected. Further disclosed are the types of tumor metastases that can be determined using the methods provided.


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