The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 09, 2021
Filed:
Apr. 14, 2016
Katholieke Universiteit Leuven, Leuven, BE;
Rijksuniversiteit Groningen, Groningen, NL;
Giovanni Maglia, Glimmen, NL;
Mikhael Soskine, Drachten, NL;
Annemie Biesemans, Kessel-Lo, BE;
Veerle Van Meervelt, Holsbeek, BE;
Bert Poolman, Haren, NL;
Gea Schuurman-Wolters, Nietap, NL;
Katholieke Universiteit Leuven, Leuven, BE;
Rijksuniversiteit Groningen, Groningen, NL;
Abstract
A method for detecting an analyte in a sample includes the steps of obtaining a nanopore sensor comprising a nanopore and a protein adaptor internalized in the lumen of the nanopore, adding a sample comprising an analyte to the cis side or the trans side of the nanopore, and measuring conductance across the nanopore. A change in conductance after adding the sample indicates the analyte is present in the sample and has bound to the protein adaptor. Nanopore sensors comprise a nanopore and a protein adaptor internalized in the lumen of the nanopore. The protein adaptor is a functional enzyme or ligand-binding protein.