The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 09, 2021

Filed:

Mar. 15, 2017
Applicant:

Ustav Organicke Chemie a Biochemie Av Cr, V.v.i., Prague, CZ;

Inventors:

Tomas Kraus, Prague, CZ;

Zbigniew Zawada, Vendryne, CZ;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C08B 37/16 (2006.01); A61K 47/40 (2006.01); G01N 33/483 (2006.01);
U.S. Cl.
CPC ...
C08B 37/0012 (2013.01); G01N 33/4833 (2013.01); A61K 47/40 (2013.01);
Abstract

Compounds of general formulae 6 and 13 where X is —NH—C(NH)═N+Hor —N+H, Y is a linear oligomer of arginine units terminated with an aminodimethylenamide unit (-Arg)n-NH—(CH)—NH, where n=6-10, or arginine-aminocaproic units (-Arg-Aca)n-NH, where n=6 to 10, A-═CFCOO— or Cl— and m=1-2. Preparation and use of compounds of general formula 6 and 13 as carriers of nucleoside triphosphates across the cell membranes for the purpose of incorporation of modified nucleoside triphosphates into cellular DNA or RNA. Use of compounds of general formula 6 and 13 as carriers of nucleoside triphosphates across the cell membrane for determining the virostatic activities of modified nucleoside triphosphates. Use of compounds of general formula 6 and 13 as carriers of modified nucleoside triphosphates across the cell membrane for determining cell proliferation and S phase of the cell cycle.


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