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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11168125 B1

PDFFull Text
Date of Patent:
Nov. 09, 2021

Filed:

Jul. 22, 2019

Immunoglobulin chimeric monomer-dimer hybrids

Applicant:

Bioverativ Therapeutics Inc., Waltham, MA (US);

Inventors:

Robert T. Peters, Needham, MA (US);

Adam R. Mezo, Waltham, MA (US);

Daniel S. Rivera, Providence, RI (US);

Alan J. Bitonti, Acton, MA (US);

Susan C. Low, Pepperell, MA (US);

Assignee:

BIOVERATIV THERAPEUTICS INC., Waltham, MA (US);

Attorneys:

Lathrop GPM LLP

James H. Velema

Primary Examiner:

Michelle S Horning

Int. Cl.
CPC ...
C07K 14/755 (2006.01); C07K 14/475 (2006.01); C07K 14/505 (2006.01); C07K 14/555 (2006.01); C07K 14/56 (2006.01); C07K 14/745 (2006.01); C07K 16/00 (2006.01); C12N 9/64 (2006.01); A61K 47/68 (2017.01); C07K 14/565 (2006.01); C12N 9/96 (2006.01); A61K 47/60 (2017.01); C07K 14/59 (2006.01); C07K 14/61 (2006.01); C07K 14/705 (2006.01); A61K 47/64 (2017.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/755 (2013.01); A61K 47/60 (2017.08); A61K 47/642 (2017.08); A61K 47/68 (2017.08); A61K 47/6803 (2017.08); A61K 47/6811 (2017.08); A61K 47/6813 (2017.08); A61K 47/6835 (2017.08); C07K 14/475 (2013.01); C07K 14/505 (2013.01); C07K 14/555 (2013.01); C07K 14/56 (2013.01); C07K 14/565 (2013.01); C07K 14/59 (2013.01); C07K 14/61 (2013.01); C07K 14/70503 (2013.01); C07K 14/745 (2013.01); C07K 16/00 (2013.01); C12N 9/644 (2013.01); C12N 9/647 (2013.01); C12N 9/6437 (2013.01); C12N 9/96 (2013.01); C12Y 304/21021 (2013.01); C12Y 304/21022 (2013.01); A61K 38/00 (2013.01); C07K 2317/52 (2013.01); C07K 2319/00 (2013.01); C07K 2319/30 (2013.01);
Abstract

The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.

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