The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 09, 2021
Filed:
Mar. 17, 2017
Applicant:
Spark Therapeutics, Inc., Philadelphia, PA (US);
Inventors:
Xavier Anguela, Philadelphia, PA (US);
Sam Hsien-I Shen, Iowa City, IA (US);
Assignee:
SPARK THERAPEUTICS, INC., Philadelphia, PA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); C07K 14/755 (2006.01); A61K 38/37 (2006.01); A61K 45/06 (2006.01); A61K 48/00 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/755 (2013.01); A61K 38/37 (2013.01); A61K 45/06 (2013.01); A61K 48/0066 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); A61K 48/00 (2013.01); C12N 2710/10342 (2013.01); C12N 2710/10343 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14145 (2013.01);
Abstract
CpG reduced nucleic acid variants encoding FVIII protein and methods of use thereof are disclosed. In particular embodiments, CpG reduced nucleic acid variants encoding FVIII are expressed more efficiently by cells, are secreted at increased levels by cells over wild-type Factor VIII proteins, exhibit enhanced expression and/or activity over wild-type Factor VIII proteins or are packaged more efficiently into viral vectors.