The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 09, 2021
Filed:
Mar. 27, 2018
Applicant:
Queen's University AT Kingston, Kingston, CA;
Inventors:
P. Andrew Evans, Kingston, CA;
Dezhi Chen, Kingston, CA;
Assignee:
Queen's University at Kingston, Kingston, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 307/93 (2006.01); A61K 47/64 (2017.01); C07C 45/63 (2006.01); C07C 67/31 (2006.01); C07F 7/18 (2006.01);
U.S. Cl.
CPC ...
C07D 307/93 (2013.01); A61K 47/64 (2017.08); C07C 45/63 (2013.01); C07C 67/31 (2013.01); C07F 7/188 (2013.01); C07F 7/1892 (2013.01);
Abstract
The present invention relates to the preparation of compounds of Formula I, including thapsigargin, nortrilobolide and 8-O-debutanoyl-thapsigargin from commercially available (R)-(−)-carvone via synthetic intermediate compound of formula 12 by pinacol coupling and in situ lactonization.