The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 09, 2021

Filed:

Sep. 08, 2017
Applicants:

University of Cincinnati, Cincinnati, OH (US);

The Hebrew University of Jerusalem, Jerusalem, IL;

University of Texas System, Austin, TX (US);

Inventors:

Nira Ben-Jonathan, Cincinnati, OH (US);

Eric R. Hugo, Cincinnati, OH (US);

Edward J. Merino, Cincinnati, OH (US);

Abraham J. Domb, Jerusalem, IL;

Armen N. Akopian, Austin, TX (US);

Assignees:

University of Cincinnati, Cincinnati, OH (US);

University of Texas System, Austin, TX (US);

The Hebrew University of Jerusalem, Jerusalem, IL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 35/00 (2006.01); A61K 9/19 (2006.01); A61K 31/135 (2006.01); A61K 31/415 (2006.01); A61K 31/475 (2006.01); A61K 45/06 (2006.01); A61K 31/53 (2006.01); C07D 253/075 (2006.01); A61K 9/00 (2006.01); A61K 33/243 (2019.01); A61K 31/122 (2006.01); A61K 31/337 (2006.01); A61K 31/4184 (2006.01); A61K 31/437 (2006.01);
U.S. Cl.
CPC ...
C07D 253/075 (2013.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 31/135 (2013.01); A61K 31/415 (2013.01); A61K 31/475 (2013.01); A61K 31/53 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); A61K 31/122 (2013.01); A61K 31/337 (2013.01); A61K 31/4184 (2013.01); A61K 31/437 (2013.01); A61K 33/243 (2019.01);
Abstract

Small molecule inhibitors (SMIs) of the Prolactin receptor, pharmaceutical compositions of the SMIs, and methods for treating patients suffering from disorders characterized increased expression or excitation of the Prolactin receptor, including breast cancer, prostate cancer and nociceptive pain disorders such as migraine headache, by administering pharmaceutical compositions of SMIs are provided.


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