The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 09, 2021
Filed:
Dec. 06, 2018
Applicant:
Glaxosmithkline Biologicals, S.a., Rixensart, BE;
Inventors:
Luis Brito, Concord, MA (US);
Michelle Chan, Florence, MA (US);
Andrew Geall, Littleton, MA (US);
Derek O'Hagan, Winchester, MA (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/39 (2006.01); A61K 9/107 (2006.01); A61K 47/06 (2006.01); A61K 47/24 (2006.01); A61K 39/12 (2006.01); A61K 39/155 (2006.01); A61K 39/245 (2006.01); A61K 47/02 (2006.01); A61K 47/12 (2006.01); A61K 47/22 (2006.01); A61K 47/26 (2006.01); A61K 47/34 (2017.01); C12N 7/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39 (2013.01); A61K 9/1075 (2013.01); A61K 39/12 (2013.01); A61K 39/155 (2013.01); A61K 39/245 (2013.01); A61K 47/02 (2013.01); A61K 47/06 (2013.01); A61K 47/12 (2013.01); A61K 47/22 (2013.01); A61K 47/24 (2013.01); A61K 47/26 (2013.01); A61K 47/34 (2013.01); C12N 7/00 (2013.01); A61K 2039/5256 (2013.01); A61K 2039/53 (2013.01); A61K 2039/55555 (2013.01); A61K 2039/55566 (2013.01); A61K 2039/575 (2013.01); C12N 2710/16134 (2013.01); C12N 2710/16171 (2013.01); C12N 2710/16734 (2013.01); C12N 2710/16771 (2013.01); C12N 2760/18534 (2013.01); C12N 2760/18571 (2013.01); C12N 2770/36134 (2013.01); C12N 2770/36143 (2013.01); C12N 2840/203 (2013.01); Y02A 50/30 (2018.01);
Abstract
This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are useful for delivering negatively charged molecules, such as nucleic acid molecules to cells, and for formulating nucleic acid-based vaccines.