The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 09, 2021
Filed:
Sep. 11, 2020
Aligos Therapeutics, Inc., South San Francisco, CA (US);
Leonid Beigelman, San Mateo, CA (US);
Rajendra Pandey, South San Francisco, CA (US);
Vivek Kumar Rajwanshi, Cupertino, CA (US);
David Bernard Smith, San Mateo, CA (US);
Lawrence M. Blatt, Healdsburg, CA (US);
Jin Hong, Brisbane, CA (US);
Aligos Therapeutics, Inc., South San Francisco, CA (US);
Abstract
Various embodiments provide STOPS™ polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS™ modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS™ modified oligonucleotides, as determined by HBsAg Secretion Assay, is greater than that of a reference compound.