The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 02, 2021

Filed:

May. 18, 2018
Applicants:

Paris Sciences ET Lettres, Paris, FR;

Centre National DE LA Recherche Scientifique, Paris, FR;

Institut Curie, Paris, FR;

Sorbonne Universite, Paris, FR;

Inventors:

Arnaud Gautier, Paris, FR;

Ludovic Jullien, Arcueil, FR;

Chenge Li, Tai yuan, CN;

Franck Perez, Paris, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); G01N 21/76 (2006.01); G01N 33/52 (2006.01); C07D 277/36 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6803 (2013.01); C07D 277/36 (2013.01); G01N 21/76 (2013.01); G01N 33/52 (2013.01);
Abstract

Fluorescent labeling of proteins. In particular, membrane-impermeant fluorogenic chromophores being capable of binding reversibly a functional derivative of a Photoactive Yellow Protein (PYP), or a functional fragment thereof, for fluorescently labeling biological molecules of interest, preferably proteins of interest. Especially, 4-hydroxybenzylidene-rhodanine (HBR) analogs of formula (II) as membrane-impermeant fluorogenic chromophores.


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