The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 02, 2021

Filed:

Apr. 21, 2021
Applicants:

The University of Kansas, Lawrence, KS (US);

Kansas State University Research Foundation, Manhattan, KS (US);

Inventor:

Mei He, Gainesville, FL (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 27/00 (2006.01); B03C 5/00 (2006.01); G01N 27/12 (2006.01); C12Q 1/6886 (2018.01); A61K 47/69 (2017.01); G01N 33/574 (2006.01); G01N 33/543 (2006.01); B03C 1/015 (2006.01); B03C 1/30 (2006.01); B01L 3/00 (2006.01); A61K 49/00 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); A61K 47/6901 (2017.08); A61K 49/0097 (2013.01); B01L 3/502715 (2013.01); B01L 3/502761 (2013.01); B03C 1/015 (2013.01); B03C 1/30 (2013.01); G01N 33/5434 (2013.01); G01N 33/54333 (2013.01); G01N 33/574 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/178 (2013.01); G01N 2446/80 (2013.01);
Abstract

Methods for producing engineered exosomes and other vesicle-like biological targets, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments.


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