The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 02, 2021
Filed:
Jul. 16, 2018
The Research Foundation for the State of University New York, Albany, NY (US);
Eckard Wimmer, East Setauket, NY (US);
Steve Skiena, Setauket, NY (US);
Steffen Mueller, Kings Point, NY (US);
Bruce Futcher, Stony Brook, NY (US);
Dimitris Papamichail, Newtown, PA (US);
John Robert Coleman, Blauvelt, NY (US);
Jeronimo Cello, Port Jefferson, NY (US);
The Research Foundation for The State University of New York, Albany, NY (US);
Abstract
This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.