The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 02, 2021
Filed:
Oct. 13, 2016
Technion Research & Development Foundation Limited, Haifa, IL;
Hadasit Medical Research Services and Development Ltd., Jerusalem, IL;
Israel Vlodavsky, Mevasseret Zion, IL;
Marina Weissmann, Netanya, IL;
Neta Ilan, Herzliya, IL;
Gil Arvatz, Kfar Tavor, IL;
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED, Haifa, IL;
HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD., Jerusalem, IL;
Abstract
The present invention relates to heparanase-neutralizing monoclonal antibodies (m Abs), pharmaceutical composition comprising same, and use thereof for treating a disease or disorder associated with heparanase activity, including but not limited to cancer, inflammation, diabetes and related complications. The present invention further provides combined therapies comprising the heparanase-neutralizing m Ab and an anti-cancer treatment such as chemotherapy or radiation, for treating a proliferative disease in a subject.