The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 02, 2021

Filed:

Aug. 09, 2018
Applicants:

Bayer Aktiengesellschaft, Leverkusen, DE;

Bayer Pharma Aktiengesellschaft, Berlin, DE;

Inventors:

Jörg Weiske, Berlin, DE;

Carlo Stresemann, Berlin, DE;

Stefan Nikolaus Gradl, Berlin, DE;

Ulrike Röhn, Berlin, DE;

Clara Christ, Berlin, DE;

Holger Steuber, Berlin, DE;

Manfred Husemann, Hohen Neuendorf, DE;

Norbert Schmees, Berlin, DE;

Kai Thede, Berlin, DE;

Stephan Siegel, Berlin, DE;

Antonius Ter Laak, Berlin, DE;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 243/12 (2006.01); C07D 401/06 (2006.01); C07D 403/06 (2006.01); C07D 409/06 (2006.01); C07D 413/06 (2006.01);
U.S. Cl.
CPC ...
C07D 243/12 (2013.01); C07D 401/06 (2013.01); C07D 403/06 (2013.01); C07D 409/06 (2013.01); C07D 413/06 (2013.01);
Abstract

The present invention covers 4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-7-carboxamide compounds of general formula (I): in which R, R, R, R, R, R, R, R, Rand X are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer, as a sole agent or in combination with other active ingredients.


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