The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 02, 2021
Filed:
Mar. 05, 2020
National Guard Health Affairs, Riyadh, SA;
King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SA;
King Abdullah International Medical Research Center, Riyadh, SA;
Imadul Islam, Riyadh, SA;
Rabih O. Al-Kaysi, Riyadh, SA;
Mohamed Boudjelal, Riyadh, SA;
Rizwan Ali, Riyadh, SA;
Atef Nehdi, Riyadh, SA;
Bandar Alghanem, Riyadh, SA;
National Guard Health Affairs, Riyadh, SA;
King Saud bin Abdulaziz University for Health Sciences, Riyadh, SA;
King Abdullah Inetrnational Medical Research Center, Riyadh, SA;
Abstract
Compounds, methods of synthesis, and methods of cancer treatment by arylidene-1,3-dioxane-4,6-diones. A Meldrum's acid-based chemistry and hybrid solid-liquid method. The method includes protection of ketone and aldehyde components and simultaneous immobilization on the solid phase, introduction of substituents, grafts and derivatives compatible with the protection, detachment and restoration of active carbonyl reactivity, reaction of ketone library with malonate, reacting of the products with the aldehyde library in liquid phase and separation of the products by preparative HPLC.